Fight or Flight? : Evolutionary Medical Structure of Immunology, its Philosophical Implications

Fight or Flight ? : Evolutionary Medical Structure of Immunology, its Philosophical Implications
Jongduck Choi
The aim of my paper is to interpret diverse relations between host and parasite by integrating evolutionary medicine and immunology. An immunological thinking could be reconstructed by specific metaphors such as ‘fighting’, ‘killing’, ‘protection’, ‘immune evasion’, ‘seizure’, or ‘coexistence’. The response of infectious microbes against the host’s attack, where the strained relations between microbes and immune system are activating, directs toward for their own surviving and reproducing through the incessant mutations of microbes as like bacteria and virus do. I will hereby show that the very philosophical category of evolutionary immunology might be formed through my thesis. It is to be unfolded as below. Firstly, I will arrange the evolutionary etiology. Secondly, I show that infectious diseases could be explained well by using the immunological metaphors. Thirdly, the relation between an evolutionary mutation of parasite and immunological activation of host will be illuminated by the concrete cases such as antibiotic, vaccine, and AZT. Fourthly, it will be highlighted that the evolution speed of mutation’s rate for infectious virus exceeds the capacity of horotelic human’s immunity. Lastly, it will be recognized that antibiotic biomedicine or antiviral medicine ultimately do not succeed in doing their role. So I suggest the necessity of medical preparation with concept of coalescence between human and microbes. My conclusion is that medical preparation of that kind of coalescence can be found in the integration of evolutionary medicine and cell based immunology.
 immunology, evolutionary medicine, vulnerability to diseases, mutation, AZT, symbiosis and coevolution, coalescence

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